VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Activity of lysosomal hydrolases and renewal of proteins in the rat liver, spleen, and thymus during antigenic stimulation and protein deficiency

   
Vasil'ev A.V., Konovalova L.S., Pletsityi K.D., Ponomareva L.G., Tutel'ian V.A.
PubMed Id: 2741402
Year: 1989  Volume: 35  Issue: 1  Pages: 92-95
Activity of cathepsins B and C was increased 1.8-2-fold in spleen simultaneously with a decrease 3.8-fold in the rate of protein renewal in the tissue lysosomal fraction within 4 days after antigen stimulation of rats, maintained within 45 days on a diet containing 5% of protein. Activation of these thiol-dependent proteinases appears to occur in response to development of immunodepressive conditions and may be related to alterations in the rate of their biosynthesis.
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Vasil'ev, A. V., Konovalova, L. S., Pletsityi, K. D., Ponomareva, L. G., Tutel'ian, V. A. (1989). Activity of lysosomal hydrolases and renewal of proteins in the rat liver, spleen, and thymus during antigenic stimulation and protein deficiency. Voprosy meditsinskoi khimii, 35(1), 92-95.
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