VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Interleukin 2-stimulated formation of ATP in T cell particles enriched with plasma membranes

   
Karelin A.A., Demidova V.S., Globa A.G., Marchuk A.I., Vtiurin B.V.
PubMed Id: 2788959
Year: 1989  Volume: 35  Issue: 3  Pages: 120-125
Distinct increase in content of ATP was found in preparations of enriched with plasmatic membranes particles from rat thymus T lymphocytes and from human peripheric blood T lymphocytes after their incubation with interleukin-2 as compared with controls which did not contain the peptide. The phenomenon observed was manifested only if these particles from T cells were preincubated with concanavalin A (2 min, 40 micrograms/ml), which is required to expression of the receptors for interleukin-2. The membrane-bound ATP, formed after the interleukin-2 effect on receptors of T lymphocytes, appears to serve as the secondary messenger activating protein kinase C.
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Karelin A.A., Demidova V.S., Globa A.G., Marchuk A.I., Vtiurin B.V. (1989) Voprosy meditsinskoi khimii, 35(3), 120-125.
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