VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

ATP-dependent transport of calcium in the myocardial sarcoplasmic reticulum during adaptation to muscular activities

   
Kalinskiĭ M.I., Gubskiĭ Iu.I., Rudnitskaia N.D., Kurskiĭ M.D.
PubMed Id: 2815676
Year: 1989  Volume: 35  Issue: 4  Pages: 31-34
Two-fold increase in Ca2+-transport properties of Ca2+-pump was detected in myocardial sarcoplasmic reticulum (SR) during adaptation of animals to muscular activity (training by means of running on treadmill within 6 weeks, with gradual increase in duration and intensity). Besides, the rate of SR membranes phosphorylation via cAMP-dependent protein kinase was increased 1.3-fold. At the same time, cAMP-dependent phosphorylation accelerated 1.4-1.5-fold the rate of ATP-dependent transport of Ca2+ in myocardial SR of both control and trained animals. The data obtained suggest that increase in the Ca2+-pump activity and in the rate of phosphorylation of SR membranes via cAMP-dependent protein kinase are of importance for adaptation of animal heart muscle to elevated activity.
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Kalinskiĭ, M. I., Gubskiĭ, Iu. I., Rudnitskaia, N. D., Kurskiĭ, M. D. (1989). ATP-dependent transport of calcium in the myocardial sarcoplasmic reticulum during adaptation to muscular activities. Voprosy Meditsinskoi Khimii, 35(4), 31-34.
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