VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Lipid peroxidation and ATPase activity in synaptosomal and mitochondrial fractions of the brain in hypoxia

   
Dzhafarov A.I., Magomedov N.M., Babaev Kh.F., Akhmedova G.Sh., Bekhbudova Z.A.
PubMed Id: 2554591
Year: 1989  Volume: 35  Issue: 4  Pages: 51-56
Acute hypoxia was accompanied by intensification of lipid peroxidation in synaptosomal and mitochondrial rat brain fractions as well as by inhibition of Na+, K+- and Mg2+-ATPases. Preadministration of antioxidants vitamin E and ionol into animals prevented distinctly the increase in lipid peroxidation rate, while the ATPases activity was unaltered. Inhibition of the ATPases may be considered as a result of impairing effect of the lipid peroxidation products, which appears to be of importance for structure-functional deteriorations of the nervous system in hypoxia.
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Dzhafarov, A. I., Magomedov, N. M., Babaev, Kh. F., Akhmedova, G. Sh., Bekhbudova, Z. A. (1989). Lipid peroxidation and ATPase activity in synaptosomal and mitochondrial fractions of the brain in hypoxia. Voprosy Meditsinskoi Khimii, 35(4), 51-56.
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