VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Cyclic AMP and cyclic GMP level in cells of spontaneously aborted fetuses with trisomic and triploid karyotypes

   
Kukharenko V.I., Khokhlova Iu.V.
PubMed Id: 2554592
Year: 1989  Volume: 35  Issue: 4  Pages: 73-75
Contents of intracellular cAMP and cGMP were studied in cultivated fibroblasts from 4 spontaneous abortuses with trisomy 7 and trisomy 9 as well as in 4 triploid cell strains. Six diploid cell strains from medical abortuses were used as controls. Distinct increase in cAMP content both calculated per I mg of cell protein or per a cell was found in trisomic strains, whereas the cAMP content increase in triploid strains was detected only per a cell. The data obtained suggest that functions of membrane complexes were impaired in the cells with anomalous karyotype.
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Kukharenko, V. I., Khokhlova, Iu. V. (1989). Cyclic AMP and cyclic GMP level in cells of spontaneously aborted fetuses with trisomic and triploid karyotypes. Voprosy meditsinskoi khimii, 35(4), 73-75.
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