VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Interleukin-1 and fibrinolysis. In vivo studies

   
Liutova L.V., Andreenko G.V., Karabasova M.A., Rybakina E.G., Kozinets I.A., Ashmarin I.P.
PubMed Id: 2815683
Year: 1989  Volume: 35  Issue: 4  Pages: 75-78
Distinct decrease in fibrinolytic activity of both whole blood plasma and its euglobulin fraction, occurring due to liberation of an inhibitor of plasminogen activator into circulation, was observed within 2-4 hrs after a single intravenous administration of rabbit interleukin-I into rats at a dose of 50 micrograms/kg, while the activator activity was increased in kidney heart, spleen and lung tissues. The similar data were obtained if the dose was either increased up to 150 micrograms/kg or decreased down to 5 micrograms/kg and 0.5 micrograms/kg, but the effect observed proved to be dose-dependent. Three injections of interleukin-I caused more pronounced increase in concentration of fibrinogen and antiplasmins as compared with controls.
Download PDF:  
Citation:

Liutova, L. V., Andreenko, G. V., Karabasova, M. A., Rybakina, E. G., Kozinets, I. A., Ashmarin, I. P. (1989). Interleukin-1 and fibrinolysis. In vivo studies. Voprosy Meditsinskoi Khimii, 35(4), 75-78.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►