VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Antithrombotic effect of protein C activator from a snake venom

   
Strukova S.M., Kogan A.E., Tara A.A., Aaviksaar A.A.
PubMed Id: 2617927
Year: 1989  Volume: 35  Issue: 5  Pages: 115-119
Influence of the protein C activator from snake venom on blood coagulation was studied. Incubation of different concentrations of the activator with rat blood plasma resulted in a dose-dependent prolongation of the activated partial thromboplastin time (APTT). Cleavage of the protein C to the active form was detected by electrophoresis. Intravenous administration of the activator (100 mg/kg) into rats led to prolongation of APTT to 242 +/- 80%, to increase in the plasminogen activator level to 145 +/- 29% and to decrease in the factor V activity to 57 +/- 14%. When thrombosis was induced by means of administration of the thromboplastin lethal dose, pretreatment with the activator prevented animal death in 90% of cases. The effects of the activator observed appear to occur via transformation of the endogenous protein C into its active form.
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Strukova S.M., Kogan A.E., Tara A.A., Aaviksaar A.A. (1989) Voprosy meditsinskoi khimii, 35(5), 115-119.
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