VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Primary culture of hepatocytes of newborn rats as a system for modeling anoxia and metabolic ischemia

   
Goncharenko T.M., Nikulina S.E., Krylova O.Yu., Stvolinskaia N.S., Poliakova E.D., Korovkin B.F.
PubMed Id: 2560870
Year: 1989  Volume: 35  Issue: 6  Pages: 51-55
A primary culture of hepatocytes from new born rats was used as an experimental model suitable for studies of the cell lysosomal apparatus and of molecular mechanisms involving cyclic nucleotides for initiation of lysosomal response to extremal conditions. Substrate deficiency and anoxia of the cultivated hepatocytes were found to cause distinct alterations in the state of lysosomal apparatus accompanied by an increase in free activity of acid phosphatase.
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Goncharenko T.M., Nikulina S.E., Krylova O.Yu., Stvolinskaia N.S., Poliakova E.D., Korovkin B.F. (1989) Voprosy meditsinskoi khimii, 35(6), 51-55.
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