VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The role of kallikrein-kinin system components in the pathogenesis of bullous skin lesions in pemphigus and pemphigoid

   
Grando S.A., Glukhen'kii B.T., Kostromin A.P., Boiko Iu.Ia., Kutsenko N.S., Korostash T.A.
PubMed Id: 2188426
Year: 1990  Volume: 36  Issue: 1  Pages: 23-27
Importance of kallikreinogenases in acantholysis and epidermo-dermal separation was shown, when the kallikreinkinin patterns were studied in blood plasma and blister fluids of 118 patients with pemphigus, of 78 patients with pemphigoid as well as of 224 guinea pigs. Under conditions of pemphigoid, as distinct from pemphigus, serine proteinases were mainly produced by active immunocytes responsible for destruction of epidermal basement membrane; activation of kinins was observed in skin impairments.
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Grando, S. A., Glukhen'kii, B. T., Kostromin, A. P., Boiko, Iu. Ia., Kutsenko, N. S., Korostash, T. A. (1990). The role of kallikrein-kinin system components in the pathogenesis of bullous skin lesions in pemphigus and pemphigoid. Voprosy Meditsinskoi Khimii, 36(1), 23-27.
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