VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Activation of cellular immunity in mice under normal conditions and in tumor growth during treatment with glucosaminyl muramyl dipeptide

   
Pimenov A.A., Rakhmilevich A.L., Deev V.V., Kirillova I.V., Migdal T.L., Andronova T.M., Fuks B.B.
PubMed Id: 2343578
Year: 1990  Volume: 36  Issue: 1  Pages: 58-60
In vitro stimulation of mice spleen cells by means of glucosaminyl muramyl dipeptide (GMDP) was accompanied by development of tumor necrosis factor and of interleukin-I. The factor was detected in blood serum only after administration of GMDP simultaneously with lipopolysaccharide. GMDP activated peritoneal macrophages; the phenomenon was evaluated by means of the macrophages ability to kill tumoral cells P815 as well as by interleukin-I production after additional stimulation with lipopolysaccharide. At the same time, an increase in proliferating activity of spleen and bone marrow cells was observed. An increase of middle lifetime and recovery of 24% mice of C57BL/6 strain with leukosis EL-4 were observed after complex treatment of the animals with GMDP, lipopolysaccharide, cyclophosphane and indomethacin.
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Pimenov, A. A., Rakhmilevich, A. L., Deev, V. V., Kirillova, I. V., Migdal, T. L., Andronova, T. M., Fuks, B. B. (1990). Activation of cellular immunity in mice under normal conditions and in tumor growth during treatment with glucosaminyl muramyl dipeptide. Voprosy Meditsinskoi Khimii, 36(1), 58-60.
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