VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Synthesis of nucleic acids and dynamics of morphological indices of the granulation tissue of skin wounds in rats treated with 4-methyluracil

   
Silaeva S.A., Khatsernova B.Ya., Golenchenko V.A., Berchenko G.N., Nikolaev A.Ya., Shekhter A.B.
PubMed Id: 1693022
Year: 1990  Volume: 36  Issue: 1  Pages: 82-84
Effect of 4-methyl uracil on dynamics of morphological patterns and the rate of nucleic acids synthesis was studied in granulation tissue developed during healing of full-layer skin wounds. Application of ointment containing 4-methyl uracil onto the wounds exhibited an antiinflammatory efficiency and decreased accumulation of leukocytes in the wound. The drug shortened the mitotic cycle in dividing fibroblasts, as a result of which periods of DNA synthesis became more frequent exhibiting two days duration. The rate of RNA synthesis was increased 1.5-2-fold. Content of acid glycosaminoglycans and collagen was increased in intercellular space surrounding fibroblasts.
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Silaeva, S. A., Khatsernova, B. Ya., Golenchenko, V. A., Berchenko, G. N., Nikolaev, A. Ya., Shekhter, A. B. (1990). Synthesis of nucleic acids and dynamics of morphological indices of the granulation tissue of skin wounds in rats treated with 4-methyluracil. Voprosy Meditsinskoi Khimii, 36(1), 82-84.
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