VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The effect of alphalphalpha-tocopherol and lidocaine on the structural-functional rearrangement of liver endoplasmic reticulum membranes after induction with phenobarbital in the postischemic period

   
Sharapov V.I., Grek O.R., Zykov A.A.
PubMed Id: 2363249
Year: 1990  Volume: 36  Issue: 2  Pages: 14-18
Inhibition of an increase in total content of unsaturated fatty acids in microsomal lipids induced by phenobarbital, alterations of parameters of the fluorescent probe 1,8-ANS-binding with membranes as well as restrictions in induction of liver microsomal monooxygenase enzymatic system were detected during postischemic period after total liver tissue ischemia. Preadministration of alpha-tocopherol and lidocaine prevented distinctly the structure-functional alterations induced by phenobarbital in liver microsomal membranes during postischemic period. Possible factors responsible for limitations of the phenobarbital inducing effect during postischemic period are discussed.
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Sharapov, V. I., Grek, O. R., Zykov, A. A. (1990). The effect of alphalphalpha-tocopherol and lidocaine on the structural-functional rearrangement of liver endoplasmic reticulum membranes after induction with phenobarbital in the postischemic period. Voprosy Meditsinskoi Khimii, 36(2), 14-18.
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