VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

1-ethoxysilatrane: ulcerostatic effect and its possible mechanisms

   
Kuznetsov I.G., Rasulov M.M., Akabirov A.A., Suslova S.K., Voronkov M.G.
PubMed Id: 2363253
Year: 1990  Volume: 36  Issue: 2  Pages: 24-27
Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.
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Kuznetsov, I. G., Rasulov, M. M., Akabirov, A. A., Suslova, S. K., Voronkov, M. G. (1990). 1-ethoxysilatrane: ulcerostatic effect and its possible mechanisms. Voprosy Meditsinskoi Khimii, 36(2), 24-27.
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