VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The effect amniocen preparation on nucleic acid metabolism in rat liver cells

   
Bozhkov A.I., Gopkalov V.G., Skliar A.I., Shereshevskaia T.M., Asadova M.K.
PubMed Id: 1694608
Year: 1990  Volume: 36  Issue: 2  Pages: 39-41
Rates of DNA and RNA synthesis as well as transport of RNA into cytoplasmic structures of rat liver cells were studied after administration of amniocen preparation. The drug did not affect the rate of DNA and RNA synthesis in intact rat liver cells, while specific radioactivity of DNA was decreased in regenerating liver tissue 24 hrs after hepatectomy. Amniocen inhibited the rate of rRNA, mRNA and tRNA transport into cytoplasm but contributed to elevated penetration of nucleic acid precursors into rat liver cells. Effect of the drug on cell membrane system appears to be responsible for its biological action related to realization of genetic information.
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Bozhkov A.I., Gopkalov V.G., Skliar A.I., Shereshevskaia T.M., Asadova M.K. (1990) Voprosy meditsinskoi khimii, 36(2), 39-41.
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