VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Modification by alpha-interferon of ethanol-induced changes in the level of opioid peptides in the rat striatum and hypophysis

   
Panchenko L.F., Terebilina N.N., Malinovskaia V.V., Manakhova L.S., Petrichenko O.B., Balashov A.M.
PubMed Id: 2382436
Year: 1990  Volume: 36  Issue: 3  Pages: 71-73
Content of Met-enkephalin in striatum and of beta-endorphin in rat hypophysis were estimated after administration of ethanol and alpha-interferon into the animals. Ethanol decreased Met-enkephalin content in striatum and of beta-endorphin in hypophysis. Preadministration of alpha-interferon into brain ventricles before ethanol administration led to an increase in concentration of Met-enkephalin, while content of beta-endorphin was unaltered. In peripheric administration alpha-interferon normalized content of beta-endorphin in adenohypophysis but did not affect the Met-enkephalin concentration. Effects of alpha-interferon on content of Met-enkephalin and beta-endorphin, related to dissimilar organization of the opiate systems in hypophysis and striatum tissues, are discussed.
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Panchenko L.F., Terebilina N.N., Malinovskaia V.V., Manakhova L.S., Petrichenko O.B., Balashov A.M. (1990) Voprosy meditsinskoi khimii, 36(3), 71-73.
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