VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Inhibition of the angiotensin-converting enzyme from bovine kidney by organophosphorus analogs of amino acids

   
Shumiantseva V.V., Gandurina I.A., Osipova T.I., Kugaevskaia E.V.
PubMed Id: 2238538
Year: 1990  Volume: 36  Issue: 4  Pages: 74-76
Reactions of amino acid phosphoorganic derivatives with angiotensin-converting enzyme (dipeptidyl carboxypeptidase) were studied. Substitution of the amino acid carboxyl group by HS- or P(O) (OH)2-groups did not cause the enzyme considerable inhibition. The enzymatic activity was inhibited by 20-50% in presence of 1 X 10(-3) M Asp, Met and Cys phosphoorganic derivatives. These amino acid derivatives may be used as potential antihypertensive drugs because of their metabolic stability and inhibitory action on the enzyme.
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Shumiantseva, V. V., Gandurina, I. A., Osipova, T. I., Kugaevskaia, E. V. (1990). Inhibition of the angiotensin-converting enzyme from bovine kidney by organophosphorus analogs of amino acids. Voprosy Meditsinskoi Khimii, 36(4), 74-76.
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