VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The effect of surgical stress on DNA synthesis in liver and brain cells

   
Iavich M.P., Rozhitskaia I.I., Golubeva L.Yu., Meerson F.Z.
PubMed Id: 2251802
Year: 1990  Volume: 36  Issue: 5  Pages: 8-11
Distinct alterations in the rate of DNA synthesis (an increase in the rate of reparation and a decrease in the rate of replication in nuclei and mitochondria) were detected in liver and brain cells during the stress caused by surgical operation. Within 8-10 hrs after the operation the rate of DNA reparation was increased by 40-50% in nuclei of liver cells and by 31-35% in brain cell nuclei. Replication of nuclear DNA was decreased immediately after the operation--by 33% in liver cells and by 50% in brain cells. Within a day after the operation the rate of replication was restored up to the control level in liver cells, while it was still decreased by 30% in brain cells. The rate of mitochondrial DNA synthesis was slightly decreased within the first 12 hrs after the operation: by 12-14% in liver cells and by 18-20% in brain cells. The stress, and particularly postoperative stress, exhibited pronounced action on structure and various systems of DNA synthesis in cells of various tissues.
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Iavich M.P., Rozhitskaia I.I., Golubeva L.Yu., Meerson F.Z. (1990) Voprosy meditsinskoi khimii, 36(5), 8-11.
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