VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Antitrypsin effects of alpha-2-macroglobulin

   
Serkhan V., Shcherbak I.G.
PubMed Id: 1706121
Year: 1990  Volume: 36  Issue: 6  Pages: 47-50
Purified preparations of alpha 2-macroglobulin were preincubated with bovine trypsin at various molar ratios. Effects of the preincubation were measured before and after addition of soybean trypsin inhibitor in excess if N-benz-L-arg-p-nitroanilide was used as a substrate. Two types of interaction between alpha 2-macroglobulin and trypsin were detected. One of them was carried out depending on the 'trap' hypothesis, another type of the interaction led to the enzyme loss of both proteolytic activity and its ability to hydrolyze the low molecular substrate. The data obtained suggest that various molecular forms of native alpha 2-macroglobulin were responsible for these types of interaction.
Download PDF:  
Citation:

Serkhan, V., Shcherbak, I. G. (1990). Antitrypsin effects of alpha-2-macroglobulin. Voprosy Meditsinskoi Khimii, 36(6), 47-50.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►