VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Prevention of cAMP stimulation of activity of various oxidative mitochondrial enzymes with lidocaine and aminazine

   
Medvedev A.E.
PubMed Id: 1963720
Year: 1990  Volume: 36  Issue: 6  Pages: 74-76
Lidocaine or aminazine (chlorpromazine) injected to rats or incubated with liver mitochondria prevented NAD-isocitrate dehydrogenase and transhydrogenase activation during the subsequent incubation of mitochondria with cAMP. Integrity of mitochondrial membranes is obligatory for manifestation of the drugs effect. Lidocaine and aminazine-induced desensitization of mitochondria to the cAMP action was apparently realized via alteration in the state (and/or composition) of lipid component of mitochondria. The significance of mitochondria sensitivity to cAMP stimulation is discussed.
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Medvedev, A. E. (1990). Prevention of cAMP stimulation of activity of various oxidative mitochondrial enzymes with lidocaine and aminazine. Voprosy Meditsinskoi Khimii, 36(6), 74-76.
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