VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Study of a series of enzyme systems and ultrastructure of rat liver in iron-manganese poisoning

   
Modenova O.A., Korolev A.A., Nikitina Z.K., Doktorov A.A.
PubMed Id: 1858339
Year: 1991  Volume: 37  Issue: 1  Pages: 39-41
During consumption of drinking water containing manganese or combination of iron and manganese several biochemical patterns were altered in animal blood and liver tissue: content of SH-groups, total lipids, activity of alkaline phosphatase, content of cytochromes b5 and P-450 in liver microsomal fractions. Light and electron microscopy showed that local unspecific alterations of hepatocytes structure occurred in liver tissue. Activation of cytochromes in response to administration of the metals appears to involve alterations in phospholipid composition of endoplasmic reticulum.
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Modenova, O. A., Korolev, A. A., Nikitina, Z. K., Doktorov, A. A. (1991). Study of a series of enzyme systems and ultrastructure of rat liver in iron-manganese poisoning. Voprosy Meditsinskoi Khimii, 37(1), 39-41.
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