VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Potentiation of the antiketogenic effect of exogenous glucose with the help of the new beta-oxidation inhibitor mildronate--3-(2,2,2-trimethylhydrazine)propionate

   
Shutenko Zh.V., Meirena D.V., Kalvin'sh I.Ia., Lukevits E.Ia.
PubMed Id: 1897198
Year: 1991  Volume: 37  Issue: 2  Pages: 59-60
Antiketogenic effect of exogenous glucose (2 g/kg, per os, 1 hr before death) was potentiated after preadministration of mildronate 3-(2,2,2-trimethylhydrazinium) propionate into rats either kept on usual ration or fasting within 48 hrs at a dose of 200 and 400 mg/kg, per os, during 10 days. Mildronate is inhibitor of carnitine-dependent metabolism of fatty acids affecting at the step of gamma-butyrobetaine turnover into carnitine. The drug inhibitory influence studied appears to be realized via activation of the glycolytic pathway of glucose metabolism specific for inhibitors of beta-oxidation.
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Shutenko Zh.V., Meirena D.V., Kalvin'sh I.Ia., Lukevits E.Ia. (1991) Voprosy meditsinskoi khimii, 37(2), 59-60.
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