VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Pharmacokinetics of human milk lactoferrin in intact mice and tumor-carrying animals

   
Kazachkina N.I., Nemtsova E.R., Iakubovskaia R.I., Karmakova T.A., Ivanova L.M., Sokolov A.V.
PubMed Id: 1949681
Year: 1991  Volume: 37  Issue: 3  Pages: 35-37
Pharmacokinetics of iodine containing and native lactoferrin from human milk was studied in intact mice and the animals with Ehrlich ascites carcinoma. Both these antigens, native and I-lactoferrin, were similarly distributed in intact mice body. The same pharmacokinetics was found in tumor-bearing animals. Exogenous lactoferrin penetrated mainly into liver tissue, then simultaneously with bile--into small intestine and further into large intestine. Distinct accumulation of the glycoprotein was not found in tumor tissue.
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Kazachkina N.I., Nemtsova E.R., Iakubovskaia R.I., Karmakova T.A., Ivanova L.M., Sokolov A.V. (1991) Voprosy meditsinskoi khimii, 37(3), 35-37.
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