VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Regulation of by arginine of cytochrome P-450 activity and lipid peroxidation in rat liver and testicular tissue during hypoxia

   
Shugaleĭ V.S., Ananian A.A., Miliutina N.P., Chin Kim T.T.
PubMed Id: 1750211
Year: 1991  Volume: 37  Issue: 4  Pages: 51-54
Arginine, preadministered intraperitoneally at a dose of 120 mg per 100 g of body mass before hypoxia, decreased content of diene conjugates by 42-64% and Schiff bases by 7-15% in rat liver and testicular microsomal membranes as compared with control rats nontreated with arginine. Under these conditions cytochrome P-450 catalytic activity with aniline as a substrate was increased by 65-152% and with amidopyrine as a substrate--by 72-148%, respectively. Exogenous arginine inhibited an increase in membranes microviscosity, specific for hypoxic state; relative microviscosity of lipid bilayer was decreased by 36% and of the protein-lipid contact zones--by 84% as compared with control hypoxic animals.
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Shugaleĭ, V. S., Ananian, A. A., Miliutina, N. P., Chin, Kim, T. T. (1991). Regulation of by arginine of cytochrome P-450 activity and lipid peroxidation in rat liver and testicular tissue during hypoxia. Voprosy Meditsinskoi Khimii, 37(4), 51-54.
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