VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Analysis of the reasons for insufficient efficacy of treating inflammatory diseases of the urogenital system in women

   
Rudenko A.V., Bavina E.N., Romashchenko O.V.
PubMed Id: 1759411
Year: 1991  Volume: 37  Issue: 5  Pages: 86-89
Concentration of tetracycline, doxicyclin and tarivide was studied in blood serum, urine and immediately in the impaired focus, in uterine tube tissue to elucidate the factors responsible for low therapeutic efficiency of drugs involved in treatment of inflammatory diseases of women urogenital system. Content of tetracycline, detected in the patients blood and urine, varied within the limits 0.02-0.12 microgram/ml and 0.003-0.136 microgram/ml, respectively, depending on the period of administration of therapeutic doses of the antibiotic. At the same time, in uterine tube tissue concentration of tetracycline was only slightly increased and constituted 0.014 microgram/ml which was distinctly lower than the minimal inhibitory content for the antibiotic. Similar results were obtained in studies of tarivide concentrations. Both morphofunctional impairments of uterine tubes and deficiency of antibiotics in the impaired focus were responsible for inadequate treatment of women with infertility of inflammatory genesis.
Download PDF:  
Citation:

Rudenko, A. V., Bavina, E. N., Romashchenko, O. V. (1991). Analysis of the reasons for insufficient efficacy of treating inflammatory diseases of the urogenital system in women. Voprosy Meditsinskoi Khimii, 37(5), 86-89.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►