Concentration of tetracycline, doxicyclin and tarivide was studied in blood serum, urine and immediately in the impaired focus, in uterine tube tissue to elucidate the factors responsible for low therapeutic efficiency of drugs involved in treatment of inflammatory diseases of women urogenital system. Content of tetracycline, detected in the patients blood and urine, varied within the limits 0.02-0.12 microgram/ml and 0.003-0.136 microgram/ml, respectively, depending on the period of administration of therapeutic doses of the antibiotic. At the same time, in uterine tube tissue concentration of tetracycline was only slightly increased and constituted 0.014 microgram/ml which was distinctly lower than the minimal inhibitory content for the antibiotic. Similar results were obtained in studies of tarivide concentrations. Both morphofunctional impairments of uterine tubes and deficiency of antibiotics in the impaired focus were responsible for inadequate treatment of women with infertility of inflammatory genesis.
Rudenko A.V. и др., Analysis of the reasons for insufficient efficacy of treating inflammatory diseases of the urogenital system in women //Voprosy meditsinskoi khimii.- 1991. -Т.37. -№ 5. С. 86-89.
Rudenko A.V. и др., "Analysis of the reasons for insufficient efficacy of treating inflammatory diseases of the urogenital system in women." Voprosy meditsinskoi khimii 37.5 (1991): 86-89.
Rudenko A.V., Bavina E.N., Romashchenko O.V. (1991). Analysis of the reasons for insufficient efficacy of treating inflammatory diseases of the urogenital system in women. Voprosy meditsinskoi khimii, 37(5), 86-89.