VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Rapid time-resolved fluoroimmunometric analysis of myoglobin

   
Gracheva E.A., Nechaeva M.V., Roshke V.V., Rykova E.Yu., Shishkin G.V., Bredikhin A.V.
PubMed Id: 1759412
Year: 1991  Volume: 37  Issue: 5  Pages: 89-92
High performance quantitative procedure for evaluation of myoglobin in blood serum is developed. The principle of two-site immunometry was used involving monoclonal antibodies against nonoverlapping epitopes of myoglobin molecule. The fluorescent compound containing europium served as a label of the antibody. Modification of the single-step assay enabled to increase the velocity of the assay to about 30 min and simplify it. The assay allowed estimation of myoglobin over a broad range of concentrations from 2 ng up to 1,000 ng/ml. The assay may be recommended for use in clinical practice for express diagnosis of myocardium infarction.
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Gracheva, E. A., Nechaeva, M. V., Roshke, V. V., Rykova, E. Yu., Shishkin, G. V., Bredikhin, A. V. (1991). Rapid time-resolved fluoroimmunometric analysis of myoglobin. Voprosy Meditsinskoi Khimii, 37(5), 89-92.
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