VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Character of changes in protease inhibitory capacity of blood in experimental osteoarticular tuberculosis

   
Titarenko O.T., Esmedliaeva D.S., Nakonechnyĭ G.D., Momot D.S., Perova T.L.
PubMed Id: 1279893
Year: 1992  Volume: 38  Issue: 1  Pages: 16-18
All the steps of osteoarticular tuberculosis evolution were accompanied by an increase in proteolytic activity in rabbit blood serum, which was compensated by activation of alpha 1-inhibitor of proteinases at the initial steps of osteitis. The system "proteinases-inhibitors" was imbalanced during the severe phases of arthritis independently on the rate of its development as follows: predominance of proteolytic potential over inhibitory activity, dissimilar activity of alpha 1-inhibitor of proteinases simultaneously with equal rate of alpha 2-macroglobulin content decrease. Dissimilar alterations in the system studied enabled to suggest that differential application of proteinases is suitable for treatment of inflammation with respect to the step of osteoarticular tuberculosis development.
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Titarenko, O. T., Esmedliaeva, D. S., Nakonechnyĭ, G. D., Momot, D. S., Perova, T. L. (1992). Character of changes in protease inhibitory capacity of blood in experimental osteoarticular tuberculosis. Voprosy Meditsinskoi Khimii, 38(1), 16-18.
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