VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Use of the magnitude of vitamin and vitamin metabolite excretion as indicators of availability of vitamins B2, B6, and niacin

   
Kodentsova V.M., Vrzhesinskaia O.A., Spirichev V.B.
PubMed Id: 1441287
Year: 1992  Volume: 38  Issue: 1  Pages: 22-25
Alimentary deficiency of riboflavin in rats caused a decrease in excretion of vitamin B2 with urine simultaneously with lowering in daily excretion of 4-pyridoxylic acid (4-PA) and N1-methyl nicotinamide (N1-MNA); these patterns are usually used as indicators of pyridoxine and niacin availability. The similar decrease in excretion of 4-PA and N1-MNA with urine but without alterations in NAD+NADP concentrations in erythrocytes was detected in women deficient in vitamin B2. Content of nicotinamide coenzymes in erythrocytes correlated with excretion of N1-MNA with urine only under normal conditions of riboflavin availability. Use of the criteria involving rates of 4-PA and N1-MNA excretion for evaluation of pyridoxine and niacin deficiency is discussed.
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Kodentsova, V. M., Vrzhesinskaia, O. A., Spirichev, V. B. (1992). Use of the magnitude of vitamin and vitamin metabolite excretion as indicators of availability of vitamins B2, B6, and niacin. Voprosy Meditsinskoi Khimii, 38(1), 22-25.
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