VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Participation of protein C in reaction of the anti-coagulant system to intravenous administration of thrombin and thromboplastin to rats

   
Kogan A.E., Strukova S.M., Tara A.A., Aaviksaar A.A.
PubMed Id: 1441296
Year: 1992  Volume: 38  Issue: 1  Pages: 48-50
Dynamics of protein C concentration was studied in rat blood after administration of thrombin and thromboplastin. Administration of 0.5 ml 1% thromboplastin caused fast decrease of protein C concentration, down to 60% of the initial level, within 3 min, while activity of factor V reached the minimal rate (30%) within 5 min. Content of protein C returned to the initial level in blood within 2-2.5 hrs and of factor V--within 6 hrs. After administration of thrombin 3 NIH in content of protein C was decreased to 91.3% whereas heparin was released only after injection of 6 NIH. The data obtained suggest that the protein C system responded earlier to occurrence of thrombin in circulation as compared with the neurohumoral regulators of the anticoagulation system; the protein C system is one of primary mechanisms of the antithrombosis defence.
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Kogan A.E., Strukova S.M., Tara A.A., Aaviksaar A.A. (1992) Voprosy meditsinskoi khimii, 38(1), 48-50.
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