VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Features of the lipid peroxidation process and antioxidant activity of white rats in extreme, multi-stage supercooling

   
Serebrennikova E.G., Mamaev A.T., Akhmedov I.G.
PubMed Id: 1413645
Year: 1992  Volume: 38  Issue: 3  Pages: 28-30
High content of polyenic fatty acids, slight increase in antioxidative activity and decrease in content of malonic dialdehyde (MDA) in rat myocardial tissues were observed in supercooling. The data obtained suggest that intensive oxidation of fatty acids occurred in the tissues, which may be essential for synthesis of biologically active substances involved in development of resistance to supercooling. Multiple supercooling caused an opposite effect in lung tissue: saturation of lipids was increased, antioxidative activity was maintained on the level similar to the control values, while content of MDA was markedly increased apparently due to destruction of metabolic products penetrating from other tissues. The dissimilar impairments of lipid metabolism were detected in liver tissue, where multiple supercooling did not alter the rate of lipid saturation, antioxidative activity was unaltered and content of MDA was as low as in the control animals.
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Serebrennikova E.G., Mamaev A.T., Akhmedov I.G. (1992) Voprosy meditsinskoi khimii, 38(3), 28-30.
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