VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Features of metabolic disorders in the liver during morphine poisoning of various duration

   
Gulyi M.F., Sinitskii V.N., Stognii N.A., Sushkova V.V., Silonova N.V., Shevtsova N.F., Kas'ianova N.N.
PubMed Id: 1413651
Year: 1992  Volume: 38  Issue: 3  Pages: 48-50
Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.
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Gulyi M.F., Sinitskii V.N., Stognii N.A., Sushkova V.V., Silonova N.V., Shevtsova N.F., Kas'ianova N.N. (1992) Voprosy meditsinskoi khimii, 38(3), 48-50.
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