VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Activity of menadione reductase and level of cytochrome B5 and P-450 in liver with varying supplies of vitamin K and administration of pelentan to rats

   
Sokol'nikov A.A., Shinkevich T.E., Kodentsova V.M., Vrzhesinskaia O.A., Spirichev V.B.
PubMed Id: 1492386
Year: 1992  Volume: 38  Issue: 5  Pages: 15-17
Content of cytochromes b5 and P-450 as well as activity of soluble menadione reductase were estimated in liver microsomes of rats deprived of vitamin K or maintained both on a diet containing excess of vicasol or antivitamin K-pelentan. Deficiency of vitamin K led to an increase in the specific activity of menadione reductase and in content of the cytochrome P-450. Administration of antivitamin K did not alter these parameters but caused an increase in the content of cytochrome b5, which was not changed in vitamin K deficiency. Dissimilar effects of alimentary deficiency in vitamin K and of pelentan administration suggest that administration of antivitamins K (although it allowed to discover alterations developed via the system of vitamin K-dependent carboxylation) could not be completely identified with alimentary vitamin K deficiency.
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Sokol'nikov, A. A., Shinkevich, T. E., Kodentsova, V. M., Vrzhesinskaia, O. A., Spirichev, V. B. (1992). Activity of menadione reductase and level of cytochrome B5 and P-450 in liver with varying supplies of vitamin K and administration of pelentan to rats. Voprosy Meditsinskoi Khimii, 38(5), 15-17.
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