VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Dependence of the initial stages of the pentose phosphate cycle on vitamin C metabolism in connective tissue pathology

   
Prosolnaya N.I.
PubMed Id: 1492396
Year: 1992  Volume: 38  Issue: 5  Pages: 41-44
Correlation between rates of oxidative and non-oxidative steps of the pentose phosphate pathway and vitamin C concentration was studied in experimental diffuse impairment of connective tissue. As compared with transketolase, activity of glucose-6-phosphate dehydrogenase was more closely dependent on concentration of ascorbic acid. Content of vitamin C was considerably altered in tissues thus demonstrating profound deterioration of vitamin C metabolism under these conditions. Simultaneous impairment of the pentose phosphate pathway primary steps and of vitamin C metabolism appear to be responsible for initiation of the diffuse injury of the connective tissue
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Reference:

Prosolnaya N.I. (1992) Voprosy meditsinskoi khimii, 38(5), 41-44.
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