Two carotene-containing drugs (natural and artificial) were shown to decrease the rate of chromosomal aberrations, induced by cyclophosphane, in bone marrow cells of mice, daily ration of which contained 10-20 mg/kg of beta-carotene within 1-3 weeks. The rate of chromosomal aberrations induced was decreased 1.5-2-fold in various experiments. Artificial beta-carotene exhibited aftereffect within at least 3 days, while its protective effect was decreased about by 20% within 7 days after administration.
Shliankevich M.A. et al. Antimutagenic properties of substances containing beta-carotene // Voprosy meditsinskoi khimii. - 1992. - V. 38. -N 6. - P. 23-25.
Shliankevich M.A. et al., "Antimutagenic properties of substances containing beta-carotene." Voprosy meditsinskoi khimii 38.6 (1992): 23-25.
Shliankevich, M. A., Drize, O. B., Khabibulina, V. M., Sergeev, A. V., Privalova, E. G., Nikitiuk, V. G. (1992). Antimutagenic properties of substances containing beta-carotene. Voprosy meditsinskoi khimii, 38(6), 23-25.