VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Immunopharmacokinetics of synthetic beta-carotene

   
Sergeev A.V., Anan'ev V.S., Vakulova L.A., Zhidkova T.A., Mukhammedzhanov S.K., Ramanauskaĭte R.Yu., Tolkachev V.N.
PubMed Id: 1298123
Year: 1992  Volume: 38  Issue: 6  Pages: 27-29
The immunopharmacology and pharmacokinetics of synthetic beta-carotene were studied in complex clinico-laboratory investigations after single and repeated per os administrations of various doses of the drug to healthy volunteers and cancer patients. Repeated treatment with beta-carotene at a dose of 30 mg caused no significant changes in the immunological parameters studied. However, treatment with a dose of 250 mg altered the parameters as follows: alteration of beta-carotene content in blood, elevation of the counts of lymphocytes and T lymphocytes forming 'active' rosettes, increase in the proliferative response of lymphocytes to the mitogen PWM and activation of natural killers. Single administration of the drug in a dose of 1,000 and 2,000 mg led to short-term reversible immunodepression, appeared as leukopenia, abolition of the proliferative response of lymphocytes to mitogens and inhibition of T suppressors. Kinetics of retinoids and beta-carotene content in blood plasma was studied after single per os administration of drug megadoses.
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Sergeev A.V., Anan'ev V.S., Vakulova L.A., Zhidkova T.A., Mukhammedzhanov S.K., Ramanauskaĭte R.Yu., Tolkachev V.N. (1992) Voprosy meditsinskoi khimii, 38(6), 27-29.
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