VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Distribution of beta-carotene in the rat upon its intraperitoneal administration in water soluble and oil forms

   
Proskuriakov S.Ya., Riabchenko N.I., Iakushina L.M., Ivannik V.P., Sin'kova R.V., Konev V.V., Popov G.A., Riabchenko V.I., Grosheva I.P.
PubMed Id: 1298132
Year: 1992  Volume: 38  Issue: 6  Pages: 47-49
Accumulation and excretion of beta-carotene in rat liver tissue were studied when the carotinoid was intraperitoneally administered as olive oil as suspension and a water liposomal suspension. Single injection of the liposomal form of beta-carotene caused an increase in its content in liver tissue. If beta-carotene was administered at a dose of 10 mg/kg its maximal content 44 mg/g of the tissue was observed within one day, and at a dose of 50 mg/kg, its maximal content constituted 178 mg/g within two days. Administration of beta-carotene as an oil suspension at a dose of 50 mg/kg led to a considerably slight accumulation in rat liver tissue with the maximal value of 12 mg/kg of the tissue within two days. Possible use of beta-carotene various forms, as well as experimental models for study their biological activity are discussed.
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Proskuriakov S.Ya., Riabchenko N.I., Iakushina L.M., Ivannik V.P., Sin'kova R.V., Konev V.V., Popov G.A., Riabchenko V.I., Grosheva I.P. (1992) Voprosy meditsinskoi khimii, 38(6), 47-49.
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