VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Activity of proteolytic enzymes and their inhibitors in experimental myocardial ischemia

   
Karapetian R.G., Oganesian S.S., Akopian T.N., Dzhanpoladian E.G.
PubMed Id: 8498066
Year: 1993  Volume: 39  Issue: 1  Pages: 29-31
Proteolytic activity and activity of endogenous inhibitors of endopeptidases (using chymotrypsin and papain) were studied in the myocardium of rats with experimental ischemia during an acute phase (60 min) and within 5 days after ligation of the left descending coronary artery; effects of the beta-adrenoblocking agent propranolol and the calcium antagonist verapamil on these activities was also studied. During the acute phase of ischemia, the activity of acid proteases was increased by 30%, that of Ca(2+)-activated neutral proteases by 15-20%. At the same time, the activity of serine proteases inhibitors was decreased while the activity of thiol protease inhibitors was increased. Within 5 days of coronary artery occlusion, Lysosomal thiol-dependent endopeptidases were activated in the myocardium; a considerably higher activity of the inhibitors of serine- and cysteine-containing endopeptidases was detected. The cardioactive drugs propranolol and verapamil affected selectively both endopeptidase activity and their inhibitors.
Download PDF:
Reference:

Karapetian R.G., Oganesian S.S., Akopian T.N., Dzhanpoladian E.G. (1993) Voprosy meditsinskoi khimii, 39(1), 29-31.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)