VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The effect of protamine on cholesterol, triglycerides and blood serum proteins during the dynamics of experimental hypercholesterolemia

   
Bozhko G.Kh., Voloshin P.V., Boĭko T.P., Kostiukovskaia L.S.
PubMed Id: 8333197
Year: 1993  Volume: 39  Issue: 3  Pages: 8-12
Content of total proteins, cholesterol, and triglycerides was studied in the blood serum and lipoprotein fractions of rabbits after administration of protamine within 1, 3 and 7 months of hypercholesterolemia development. The protamine effect was accompanied by "equalization" of cholesterol and triglyceride concentrations, as compared with their alteration in hypercholesterolemia, by stabilization of their content in various periods of the disease, but at the higher level than that of intact animals. The phenomenon observed occurred mainly in lipid components of LDL and VLDL subfractions. Analysis of alterations in the content of cholesterol and proteins in HDL and apo B-containing fractions showed that administration of protamine during long-term hypercholesterolemia led to development of antiatherogenic symptoms. Proatherogenic alterations in lipoprotein composition, developed during hypercholesterolemia, appear to be inhibited by protamine.
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Bozhko, G. Kh., Voloshin, P. V., Boĭko, T. P., Kostiukovskaia, L. S. (1993). The effect of protamine on cholesterol, triglycerides and blood serum proteins during the dynamics of experimental hypercholesterolemia. Voprosy Meditsinskoi Khimii, 39(3), 8-12.
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