VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Correlation of lipid peroxidation intensity and insulin reception in adipocytes

   
Ivanov V.V., Stennikova M.P.
PubMed Id: 8379107
Year: 1993  Volume: 39  Issue: 4  Pages: 23-25
Influence of prooxidants (cumene hydroperoxide and Fe2+) on insulin reception by adipocytes was studied in experimental conditions. Cumene hydroperoxide (10(-7) M) in the presence of Fe2+ (0.2 mM) increased the specific binding of the hormone. The higher concentrations (10(-6)-10(-3) M) of the prooxidant resulted in significant accumulation of malonic dialdehyde and inhibited insulin binding by fat tissue cells. The inhibition of insulin specific binding was shown to occur due to a decrease in the content of insulin receptors as well as in the rate of their affinity to the hormone.
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Ivanov V.V., Stennikova M.P. (1993) Voprosy meditsinskoi khimii, 39(4), 23-25.
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