VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Detection of combined forms of hemoglobino- and enzymopathies in newborns

   
Askerova T.A., Movsum-zade K.M., Kichibekov B.R.
PubMed Id: 8303876
Year: 1993  Volume: 39  Issue: 6  Pages: 51-54
In order to develop a rational and early detection of combined forms of hemoglobin and enzymopathies, 1500 samples of neonatal cord blood were tested for alpha- and beta-thalassemia, of abnormal hemoglobins S and C, of methemoglobinemia and for hereditary persistence of fetal hemoglobin as well as 428 samples were examined for glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and glutathione reductase (EC 1.6.4.2) deficiencies. For this purpose, isoelectrofocusing in Multiphor-2117 polyacrylamide-ampholine plates (LKB, Sweden) at pN 3.5-9.5 and pH 5.5-8.5 was carried out with subsequent laser densitometry of gels (Densitometer 2202, LKB). The data obtained were analyzed simultaneously in biochemical, hematological and genealogical studies. Hereditary impairments detected were evidenced by genealogical analysis.
Download PDF:  
Citation:

Askerova, T. A., Movsum-zade, K. M., Kichibekov, B. R. (1993). Detection of combined forms of hemoglobino- and enzymopathies in newborns. Voprosy Meditsinskoi Khimii, 39(6), 51-54.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►