VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Change in the oxidative metabolism of macrophages during transformation into foam cells

   
Zenkov N.K., Dushkin M.I., Liubimov G.Iu., Men'shchikova E.B.
PubMed Id: 8122402
Year: 1994  Volume: 40  Issue: 1  Pages: 2-4
Oxidative metabolism of murine peritoneal macrophages was studied after cultivation in a mixture containing acetylated low density lipoproteins within 24 and 48 hr using luminol- and lucigenin-dependent chemiluminescence. Chemiluminescence of foamy cells, induced by opsonized zymosan, was not distinctly altered as compared with native macrophages; at the same time, the rate of both lucigenin- and luminol-dependent spontaneous chemiluminescence was distinctly decreased. The imbalance of the oxidative reactions observed enables the authors to propose the antioxidative mechanism of atherosclerotic lesion.
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Zenkov, N. K., Dushkin, M. I., Liubimov, G. Iu., Men'shchikova, E. B. (1994). Change in the oxidative metabolism of macrophages during transformation into foam cells. Voprosy meditsinskoi khimii, 40(1), 2-4.
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