VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The effect of adrenaline on the activity and functional mobility of transhydrogenase in the inner mitochondrial membrane

   
Medvedev A.E.
PubMed Id: 8122418
Year: 1994  Volume: 40  Issue: 1  Pages: 7-10
Adrenaline injection to rats increased activity of liver mitochondrial transhydrogenase. Transhydrogenase in the adrenaline activated submitochondrial particles showed increased sensitivity to thermal and proteolytic inactivations as well as to inhibition by dicyclohexyl carbodiimide. Substrates of the reaction NAD+ and NADPH, which induce different conformational changes of the enzyme molecule in membranes, alternated to a greater extent the sensitivity to these treatments of transhydrogenase in the adrenaline activated submitochondrial particles as compared with controls. Activation of transhydrogenase by catecholamines appears to occur due to increase of the enzyme molecule mobility in the inner mitochondrial membrane.
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Reference:

Medvedev A.E. (1994) Voprosy meditsinskoi khimii, 40(1), 7-10.
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