Characteristics of the humoral immune system and lipid peroxidation processes in people living in territories contaminated with radionuclides

Vasil'ev A.V., Samsonov M.A., Pokrovskii V.B., Pokrovskaia G.R., Levachev M.M.
PubMed Id: 8160422
Year: 1994  Volume: 40  Issue: 2  Pages: 21-24
Among 33 patients with Stage II hypertension, 25 persons were inhabitants of the Russian radionuclide-contaminated areas and 8 patients had no prior contacts with ionizing radiation (control). All the patients examined were maintained within 4 weeks on a diet, radioprotective effect of which was realized due to the elevated content of sulfur containing amino acids, antioxidants and complexes. In the patients who lived in the radionuclide-contaminated areas, a moderate activation of lipid peroxidation was detected simultaneously with marked alterations in the humoral component of the immunity system, which involved a considerable increase in the levels of IgG and complements C3 and C4. A decrease in content of malonic dialdehyde and diene conjugates as well as normalization of IgG and decrease in content of IgA, IgM and C3 were observed in blood plasma of the patients on diet. Supplementation of omega 3 polyunsaturated fatty acids (omega 3-PUFA), 5 g/day and alpha-tocopherol, 12.5 mg/day, to the diet elevated the serum concentrations of all lg classes, which suggests the presence of an immunomodulating effect of omega 3-PUFA. Moreover, the content of malonic dialdehyde was not increased in blood plasma if 3-PUFA was used. Hence, increased alpha-tocopherol levels should be used in the treatment of these patients with omega 3-PUFA (up to 5-7 mg per g PUFA) in order to stabilize lipid peroxidation.
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Vasil'ev A.V., Samsonov M.A., Pokrovskii V.B., Pokrovskaia G.R., Levachev M.M. (1994) Voprosy meditsinskoi khimii, 40(2), 21-24.
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