40 rabbits were used in the experiments, where 10 animals were in control group, and 3 groups of the animals were treated with naphthalene oil obtained from various pit-holes NN 39, 54 and 88. The treatment course included 10 applications of naphthalene oil, which was placed on lateral body surface, 10 x 10 cm, a dose of 1.0 ml/kg, within 10 min. A state of lipid peroxidation was evaluated by measurement of hydroperoxides, diene conjugates and malonic dialdehyde in rabbit blood. Some decrease in content of lipoperoxides was observed in rabbits after the course of naphthalene oil treatment and the oil from the pit-hole 54 exhibited the highest effect. These results may be involved in evaluation of the naphthalene oil medicinal effects as well as in working out recommendations to use the naphthalene oil not from usual reservoir, but namely from pit-hole 54 for treatment of patients with impaired lipid metabolism.