VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Fibrinolytic and thrombolytic properties of the drug morikrase

   
Andreenko G.V., Liutova L.V., Rudenskaia G.N., Karabasova M.A., Kupenko O.G., Isaev V.A.
PubMed Id: 8079439
Year: 1994  Volume: 40  Issue: 3  Pages: 43-46
Fibrinolytic and thrombolytic properties of morikrase, a complex of proteinases obtained from hepatopancreatic tissues of king crab (Paralithodes camtschatica), were studied in vivo and in vitro. High fibrinolytic activity and dose-dependent activating properties were detected on standard and heated fibrin plates. The preparation maintained its properties during long-term storage at 4 degrees and 22 degrees C. The thrombolytic activity of the drug, affecting the preformed thrombus, was observed both in vitro and in vivo, in rats with experimental thrombosis. Two-phase alteration of the fibrinolytic system and moderate hypocoagulation were found after intravenous administration of morikrase.
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Andreenko, G. V., Liutova, L. V., Rudenskaia, G. N., Karabasova, M. A., Kupenko, O. G., Isaev, V. A. (1994). Fibrinolytic and thrombolytic properties of the drug morikrase. Voprosy meditsinskoi khimii, 40(3), 43-46.
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