Fibrinolytic and thrombolytic properties of morikrase, a complex of proteinases obtained from hepatopancreatic tissues of king crab (Paralithodes camtschatica), were studied in vivo and in vitro. High fibrinolytic activity and dose-dependent activating properties were detected on standard and heated fibrin plates. The preparation maintained its properties during long-term storage at 4 degrees and 22 degrees C. The thrombolytic activity of the drug, affecting the preformed thrombus, was observed both in vitro and in vivo, in rats with experimental thrombosis. Two-phase alteration of the fibrinolytic system and moderate hypocoagulation were found after intravenous administration of morikrase.
Andreenko G.V. et al. Fibrinolytic and thrombolytic properties of the drug morikrase // Voprosy meditsinskoi khimii. - 1994. - V. 40. -N 3. - P. 43-46.
Andreenko G.V. et al., "Fibrinolytic and thrombolytic properties of the drug morikrase." Voprosy meditsinskoi khimii 40.3 (1994): 43-46.
Andreenko, G. V., Liutova, L. V., Rudenskaia, G. N., Karabasova, M. A., Kupenko, O. G., Isaev, V. A. (1994). Fibrinolytic and thrombolytic properties of the drug morikrase. Voprosy meditsinskoi khimii, 40(3), 43-46.