VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The antioxidant defense system in hypertension patients on a diet enriched with omega 3 polyunsaturated fatty acids and alphalphalpha-tocopherol

   
Vasil'ev A.V., Biiasheva I.R., Pokrovskaia G.R., Mal'tsev G.Iu., Varsanovich E.A., Orlova L.A., Soto S.Kh.
PubMed Id: 8079443
Year: 1994  Volume: 40  Issue: 3  Pages: 53-56
A state of the anti-oxidation system in blood and the rate of lipid peroxidation were studied in patients with hypertension. High sensitivity of the anti-oxidation system enzymes to alterations in the diet fat composition was detected in the patients, nutrition of whom was evaluated in detail. Excessive doses of alpha-tocopherol, added to the diet enriched with omega 3-polyunsaturated fatty acids normalized lipid peroxidation and stabilized the enzyme activity involved in the anti-oxidation system. The integral parameter, proposed for evaluation of the anti-oxidation protection state and designated as 'anti-oxidation index' involved estimation of catalase, superoxide dismutase, glutathione reductase and peroxidase activities as well as of content of malonic dialdehyde and diene conjugates in erythrocytes
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Vasil'ev, A. V., Biiasheva, I. R., Pokrovskaia, G. R., Mal'tsev, G. Iu., Varsanovich, E. A., Orlova, L. A., Soto, S. Kh. (1994). The antioxidant defense system in hypertension patients on a diet enriched with omega 3 polyunsaturated fatty acids and alphalphalpha-tocopherol. Voprosy Meditsinskoi Khimii, 40(3), 53-56.
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