VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Cellular mechanisms of calcium regulation of cardiac rhythm in children with ectopic arrhythmias

   
Bershova T.V., Bakanov M.I., Bokeriia L.A., Serbin V.I., Mamedova T.N., Mikhaĭlova I.L.
PubMed Id: 7526547
Year: 1994  Volume: 40  Issue: 4  Pages: 50-53
Regulation of intracellular calcium homeostasis by means of secondary mediators calmodulin and 4,5-inositol phosphates (products of phosphatidyl inositol hydrolysis) was studied in children with ectopic forms of arrhythmias. Alterations in the system calmodulin-Ca2+ and the activity of phosphoinosite metabolism correlated highly with clinical manifestations of the arrhythmias. The data obtained suggest that a number of molecular mechanisms and responsible for arrhythmias were realized in cell membranes and depended on a complex of intracellular messengers affected within various steps of the hormonal signal transmission.
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Bershova, T. V., Bakanov, M. I., Bokeriia, L. A., Serbin, V. I., Mamedova, T. N., Mikhaĭlova, I. L. (1994). Cellular mechanisms of calcium regulation of cardiac rhythm in children with ectopic arrhythmias. Voprosy Meditsinskoi Khimii, 40(4), 50-53.
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