VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Ubiquinones and the body's antimutagenic defense

   
Georgiev V.N., Durnev A.D., Seredenin S.B.
PubMed Id: 7839677
Year: 1994  Volume: 40  Issue: 5  Pages: 8-9
The effects of ubiquinone-10 given in oral doses of 0.2-20 mg/kg on cytogenetic effects of intraperitoneal photrinum (7 and 14 mg/kg), dioxydinum (100 and 300 mg/kg) and cyclophosphanum (20 mg/kg) were studied in the bone marrow metaphasic cells of male C57Bl/6 mice. Ubiquinone-10 (2 to 20 mg/kg) statistically significantly reduced the clastogenic action of these mutagens, except photrinum used in a dose of 7 mg/kg. The antimutagenic effect of the drug was dose-independent and no more than 50%. The findings enable ubiquinone-10 be considered as an endogenous antimutagen. It is suggested that the antimutagenic activity of the compound is due to its antioxidative properties
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Georgiev V.N., Durnev A.D., Seredenin S.B. (1994) Voprosy meditsinskoi khimii, 40(5), 8-9.
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