VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The nitric oxide cycle in mammals and nitrite reducing activity of heme-containing proteins

   
Reutov V.P., Sorokina E.G., Kaiushin L.P.
PubMed Id: 7618297
Year: 1994  Volume: 40  Issue: 6  Pages: 31-35
A nitric oxide cycle is proposed, which explains numerous experimental data demonstrating that under hypoxic conditions synthesis of NO was elevated. Two pathways appear to be fundamental for activation of NO formation: 1) activation of L-arginine utilization as its content was decreased in blood; 2) transfer of heme-containing proteins hemoglobin, myoglobin, cytochrome oxidase and cytochrome P-450 into their deoxy-form, where these proteins are able to reduce NO2- into NO. This suggests that the nitric oxide cycle may be considered as a compensatory mechanism which allowed the various cells to acquire reduced dependence on overloading under conditions of oxygen and energy deficiency
Download PDF:  
Citation:

Reutov, V. P., Sorokina, E. G., Kaiushin, L. P. (1994). The nitric oxide cycle in mammals and nitrite reducing activity of heme-containing proteins. Voprosy Meditsinskoi Khimii, 40(6), 31-35.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►