The following patterns should be recommended as a criterion of normal vitamin B2 requirements: the FAD-effect is no more than 1.25, the levels of riboflavin, more than 5 ng/ml in the plasma and more than 130 ng/ml in the erythrocytes. At the same time, the hourly urinary riboflavin excretion more than 10 g/h may be used as a criterion of normal vitamin B2 requirements in children of 5-7 years old. These values were obtained while analysing the many-year experimental data on riboflavin treatment and using the mathematical analysis of the dependence curves for the urinary riboflavin excretion, its levels in plasma and erythrocytes, and the value of the FAD effect, as well as deriving and mathematically interpreting the variation curvers for the distribution of the given value of the FAD effect and the plasma riboflavin levels for human beings after additional vitamin therapy.
Vrzhesinskaia O.A. et al. Refining criteria for providing the body with vitamin B2 // Voprosy meditsinskoi khimii. - 1994. - V. 40. -N 6. - P. 41-44.
Vrzhesinskaia O.A. et al., "Refining criteria for providing the body with vitamin B2." Voprosy meditsinskoi khimii 40.6 (1994): 41-44.
Vrzhesinskaia, O. A., Kodentsova, V. M., Kharitonchik, L. A., Alekseeva, I. A., Risnik, V. V., Spirichev, V. B. (1994). Refining criteria for providing the body with vitamin B2. Voprosy meditsinskoi khimii, 40(6), 41-44.